Poop transplants have become routine treatment for nasty recurrent diarrheal infections, but trials for other conditions have hit a bum note. Now, the fecal faithful have re-examined the evidence.
Time and again, they found one donor whose stool was substantially more likely to lead to clinical improvement than others in the same trial. These ‘super-donors’ can provide the necessary bacteria to restore gut chemicals that are lacking in illnesses like IBD and diabetes, according to a new review published in Frontiers in Cellular and Infection Microbiology. With Alzheimer’s, multiple sclerosis, cancers, asthma, allergies and heart disease all associated with changes to gut bacteria as well, understanding what makes a fecal super donor could make poop the new panacea. Fecal transplants from super donors have high success rates
“The last two decades have seen a growing list of medical conditions associated with changes in the microbiome — bacteria, viruses and fungi, especially in the gut,” says senior author Dr Justin O’Sullivan of the University of Auckland.
“In fact, we know already that changes to the gut microbiome can contribute to disease, based on studies in germ-free mice as well as clinical improvement in human patients following restoration of the gut microbiome by transplanting stool from a healthy donor.”
While the overall cure rate for recurrent diarrheal infection exceeds 90%, trials of fecal transplantation for other conditions like inflammatory bowel disease exacerbations and type 2 diabetes have had much more mixed results, averaging nearer 20%.
“The pattern of success in these trials demonstrates the existence of ‘super-donors’, whose stool is particularly likely to influence the host gut and to lead to clinical improvement,” explains O’Sullivan.
“We see transplants from super-donors achieve clinical remission rates of perhaps double the remaining average. Our hope is that if we can discover how this happens, then we can improve the success of fecal transplantation and even trial it for new microbiome-associated conditions like Alzheimer’s, multiple sclerosis and asthma.”
Super stool is rich in bacteria that enhance our metabolism
O’Sullivan and colleagues reviewed fecal transplantation trials for clues to the origin of the super-donor phenomenon.
“It is well-known that responders typically exhibit a higher microbial diversity than non-responders. In line with these observations, a larger number of species in the donor stool has been shown to be one of the most significant factors influencing fecal transplantation outcome,” O’Sullivan explains.
In particular, super donor stool tends to have high levels of specific ‘keystone species’. These are bacteria which produce chemicals whose lack in the host gut contributes to disease.
“In inflammatory bowel disease and diabetes for example, keystone species that are associated with prolonged clinical remission produce butyrate – a chemical with specialized functions in regulating the immune system and energy metabolism.”
The keystone species theory can be tested, of course, by selecting donor stool rich in particular strains – or by designing ‘precision’ transplants with a defined mixture of beneficial bacteria, like a probiotic.
“This approach has been applied successfully to prevent complications in a small sample of patients with liver disease. However, this study showed that microbial enrichment in the donor does not completely guarantee enrichment in the recipient.”